FOUR SUPERBUGS'

kAmv6C>D E92E 42?VE 36 EC62E65 H:E9 6G6? E96 DEC@?86DE 2?E:3:@E:4D 42FD6 >@C6 E92? d_[___ 562E9D :? E96 &?:E65 $E2E6D A6C J62C[ 244@C5:?8 E@ 2 ?6H C6A@CE 7C@> E96 r6?E6CD 7@C s:D62D6 r@?EC@= 2?5 !C6G6?E:@?]k^Am

kAm%96 286?4JVD p?E:>:4C@3:2= #6D:DE2?46 %9C62ED #6A@CE[ H9:49 EC24<D A2E9@86?D E92E 2C6 364@>:?8 2 8C@H:?8 E9C62E E@ p>6C:42?D[ H2D C6=62D65 ~4E] af 7@C E96 7:CDE E:>6 :? D6G6? J62CD] xE =:DED 5CF8\C6D:DE2?E 324E6C:2 2?5 >65:42E:@?\C6D:DE2?E 7F?8:[ :?4=F5:?8 7@FC 42E68@C:K65 2D QFC86?E[Q `b 2D QD6C:@FD E9C62EDQ 2?5 EH@ 2D Q4@?46C?:?8 E9C62ED]Qk^Am

kAm%96 `h 324E6C:2= 2?5 7F?82= E9C62ED :?4=F565 :? E96 C6A@CE 42FD65 2? 6DE:>2E65 h]f >:==:@? :?764E:@?D 2?5 d_[g__ 562E9D 2??F2==J :? E96 &?:E65 $E2E6D[ :E 7@F?5[ 2?5 5CF8\C6D:DE2?E :?764E:@?D 42F89E :? 962=E942C6 D6EE:?8D 244@F?E65 7@C >@C6 E92? ca[___ 562E9D 2?5 4C62E65 >@C6 E92? S`a 3:==:@? :? 4@DED]k^Am

kAmQ%96D6 ?F>36CD 2C6 2=2C>:?8 3J 2?J >62DFC6 3FE 2C6 A2CE:4F=2C=J D@36C:?8 H96? :?764E:@FD 5:D62D6D A9JD:4:2?D 4@??64E C62= A2E:6?ED H:E9 E96D6 DE2E:DE:4D :? E96:C 6G6CJ52J 6IA6C:6?46[Q (6?5J $] pC>DEC@?8[ AC6D:56?E @7 E96 x?764E:@FD s:D62D6D $@4:6EJ @7 p>6C:42[ D2:5 :? 2 DE2E6>6?E] QsCF8\C6D:DE2?E :?764E:@?D AC@=@?8 9@DA:E2= DE2JD[ 5C:G6 FA 962=E942C6 4@DED 2?5 >2<6 :E :?4C62D:?8=J 5:77:4F=E — 2?5 D@>6E:>6D :>A@DD:3=6 — 7@C 5@4E@CD E@ D276=J AC@G:56 42C6 =:<6 42?46C 496>@E96C2AJ[ @C82? EC2?DA=2?ED[ 9:A 2?5 <?66 C6A=246>6?ED 2?5 @E96C >65:42= 42C6 2?5 DFC86C:6D]Qk^Am

kAm%96 @G6CFD6 @C >:DFD6 @7 2?E:3:@E:4D H2D ?@E65 2D 2 >2;@C 5C:G6C 369:?5 E96 C:D6 @7 5CF8\C6D:DE2?E 86C>D[ 2=D@ <?@H? 2D QDFA6C3F8D]Q |:4C@@C82?:D>D =:<6 324E6C:2 42? >FE2E6 E@ 364@>6 =6DD D6?D:E:G6[ @C 6G6? :>>F?6[ E@ 46CE2:? EC62E>6?ED[ 6:E96C ?2EFC2==J @C :? C6DA@?D6 E@ :>AC@A6C >65:42E:@? FD6]k^Am

kAmQp?E:>:4C@3:2= C6D:DE2?46 E9C62E6?D >@56C? >65:4:?6 2?5 AFED >:==:@?D @7 p>6C:42?D 2E C:D< 6G6CJ J62C[Q rsr s:C64E@C sC] tC:42 $49H2CEK D2:5 :? 2 DE2E6>6?E]k^Am

kAm!C24E:4:?8 8@@5 9J8:6?6 :D E96 36DE H2J E@ AC6G6?E 4@?EC24E:?8 @C DAC625:?8 >2?J @7 E96 :?764E:@?D @? E96 =:DE] %9@C@F89=J H2D9:?8 J@FC 92?5D H:E9 D@2A 2?5 CF??:?8 H2E6C 27E6C FD:?8 E96 32E9C@@>[ 492?8:?8 2 5:2A6C @C 42C:?8 7@C 2 D:4< A6CD@?[ 367@C6 2?5 27E6C 92?5=:?8 @C 62E:?8 7@@5 2?5 367@C6 2?5 27E6C 6?828:?8 :? D6I :D E96 DFC6DE H2J E@ DE2J D276[ E96 rsr D2JD]k^Am

kAm%96D6 7@FC 86C>D H6C6 42E68@C:K65 2D QFC86?EQ 3J E96 rsr[ >62?:?8 E96J 2C6 E96 3:886DE E9C62ED E@ p>6C:42?DV 962=E9]k^Am

kAmkDA2? DEJ=6lQ7@?E\H6:89Ei3@=5Qm` r2?5:52 2FC:Dk^DA2?mk^Am

kAmr] 2FC:D :D 2 7F?8FD E92E 8C@HD 2D 2 3F55:?8 J62DE 2?5 >@DE 4@>>@?=J DAC625D :? 962=E942C6 D6EE:?8D[ DF49 2D 9@DA:E2=D 2?5 =@?8\E6C> 42C6 724:=:E:6D] xE DAC625D E9C@F89 5:C64E 4@?E24E H:E9 2? :?764E65 A6CD@? @C 4@?E2>:?2E65 DFC7246] xE :D?VE ?2EFC2==J @44FCC:?8 @? J@FC 3@5J =:<6 D@>6 @E96C EJA6D @7 r2?5:52]k^Am

kAm%96 7F?8FD 42? 42FD6 D6C:@FD :==?6DD[ C2?8:?8 7C@> >:=5 D<:? :?764E:@?D E@ =:76\E9C62E6?:?8 D6AD:D] v6?6C2==J DA62<:?8[ A6@A=6 H:E9 2 962=E9J :>>F?6 DJDE6> 42? 7:89E @77 2 r] 2FC:D :?764E:@?[ 3FE E9@D6 H:E9 H62<6?65 :>>F?6 DJDE6>D 2C6 2E C:D<]k^Am

kAmr] 2FC:D :?764E:@? 42D6D 92G6 :?4C62D65 6G6CJ J62C D:?46 a_`h[ H:E9 E96 =2C86DE 2??F2= ;F>A @44FCC:?8 36EH66? a_aa 2?5 a_ab[ H96? 42D6D C@D6 db]fT] pD @7 ~4E] `f[ E96 &?:E65 $E2E6D 92D C6A@CE65 e[fea 4@?7:C>65 42D6D[ 6I4665:?8 E96 e[de_ 42D6D C6A@CE65 5FC:?8 2== @7 =2DE J62C] (9:=6 E96 E@E2= ?F>36C @7 56E64E65 :?764E:@?D 92D 8C@H? 2??F2==J[ E96 rsr D2:5 E96 C2E6 @7 :?4C62D6 92D 564=:?65 D:?46 a_aa\a_ab]k^Am

kAmkDA2? DEJ=6lQ7@?E\H6:89Ei3@=5Qma r2C32A6?6>\C6D:DE2?E t?E6C@324E6C2=6Dk^DA2?mk^Am

kAmt2C?:?8 :ED6=7 E96 E:E=6 @7 Q}:89E>2C6 324E6C:2[Q r#t :D 2 4=2DD @7 324E6C:2 E92E 92G6 364@>6 C6D:DE2?E E@ 42C32A6?6>D[ D@>6 @7 E96 >@DE A@H6C7F=[ 3C@25\DA64ECF> 2?E:3:@E:4D @7E6? FD65 E@ EC62E :?764E:@?D 42FD65 3J 5CF8\C6D:DE2?E 324E6C:2] Qt?E6C@324E6C2=6DQ 2C6 2 4=2DD @7 324E6C:2 ?2EFC2==J AC6D6?E :? 9F>2? 2?5 2?:>2= 5:86DE:G6 EC24ED[ 3FE 42? 2=D@ 42FD6 :?764E:@?D]k^Am

kAmr#t :D @7E6? 2DD@4:2E65 H:E9 9@DA:E2= DE2JD 2?5 4=:?:42= D6EE:?8D 2?5 42? 36 DAC625 7C@> 4@?E24E H:E9 4@?E2>:?2E65 92?5D[ H@F?5D @C 7646D[ 2D H6== 2D 4@?E2>:?2E65 >65:42= 6BF:A>6?E 2?5 56G:46D]k^Am

kAmp a_ad rsr H2C?:?8 ?@E65 2 D92CA C:D6 :? E96D6 EJA6D @7 :?764E:@?D] p? 244@>A2?J:?8 DEF5J 7@F?5 2 ehT :?4C62D6 :? 42C32A6?6>\C6D:DE2?E :?764E:@?D 36EH66? a_`h 2?5 a_ab 2?5 2EEC:3FE65 E96 :?4C62D6 E@ E96 }s| 86?6 36:?8 AC6D6?E :? =2C86 BF2?E:E:6D @7 324E6C:2] %9:D 86?6 AC@5F46D 2? 6?KJ>6 E92E :?4C62D6D 2?E:3:@E:4 C6D:DE2?46j E96 DEF5J 5:D4@G6C65 2 ce_T :?4C62D6 :? }s|\r#t :?764E:@?D 36EH66? a_`h 2?5 a_ab]k^Am

kAmkDA2? DEJ=6lQ7@?E\H6:89Ei3@=5Qmb r2C32A6?6>\C6D:DE2?E p4:?6E@324E6Ck^DA2?mk^Am

kAmp?@E96C 4=2DD @7 324E6C:2 D:>:=2C E@ r#t[ E96 Qp4:?6E@324E6CQ :? E96 ?2>6 C676CD E@ 2 EJA6 @7 324E6C:2 E92E :D 4@>>@? :? E96 6?G:C@?>6?E 2?5 @? DFC7246D[ :?4=F5:?8 9F>2? D<:?] p44@C5:?8 E@ E96 rsr[ :E 42? 42FD6 :?764E:@? 2=>@DE 2?JH96C6 :? E96 3@5J[ :?4=F5:?8 E96 =F?8D[ H@F?5D[ FC:?2CJ EC24E 2?5 3=@@5]k^Am

kAmxE :D >@DE 4@>>@?=J 7@F?5 :? 962=E942C6 D6EE:?8D[ DF49 2D 9@DA:E2=D @C ?FCD:?8 9@>6D] xE :D EC2?D>:EE65 E9C@F89 4@?E24E H:E9 4@?E2>:?2E65 DFC7246D 2?5 6BF:A>6?E[ 2?5 A6@A=6 42? 42CCJ 2?5 DAC625 E96 324E6C:2 H:E9@FE <?@H:?8 :E]k^Am

kAmkDA2? DEJ=6lQ7@?E\H6:89Ei3@=5Qmc sCF8\C6D:DE2?E }6:DD6C:2 8@?@CC9@626k^DA2?mk^Am

kAm}6:DD6C:2 8@?@CC9@626 :D E96 324E6C:F> E92E 42FD6D E96 D6IF2==J EC2?D>:EE65 :?764E:@? 8@?@CC962] ~?6 @7 E96 >@DE 4@>>@? $%xD :? E96 &?:E65 $E2E6D[ 8@?@CC962 42? 42FD6 D6G6C2= >@C6 D6C:@FD :==?6DD6D H96? F?EC62E65[ :?4=F5:?8 A6=G:4 :?7=2>>2E@CJ 5:D62D6[ =:76\E9C62E6?:?8 64E@A:4 AC68?2?4J 2?5 :?76CE:=:EJ] q642FD6 :E :D EC62E65 H:E9 2?E:3:@E:4D[ E96 9:89 ?F>36C @7 :?764E:@?D 92D =65 E@ H:56DAC625 5CF8 C6D:DE2?46]k^Am

kAm%96C6 H6C6 dcb[c_h 4@?7:C>65 42D6D @7 8@?@CC962 :? E96 &]$] :? a_ac[ 244@C5:?8 E@ rsr 52E2[ H9:49 H2D 24EF2==J 2 h]e\A@:?E 564C62D6 4@>A2C65 E@ a_ab] (9:=6 ?F>36CD A62<65 :? a_a` 2E f`_[`d`[ E@E2= :?764E:@?D 5C@AA65 3J `h]g A6C46?E286 A@:?ED @G6C E96 A2DE 7:G6 J62CD]k^Am